450 rpm gearing

Is there any issue with gearing 450 rpm and using the top row of the c channel for the gearing?

What gears do you plan to use for this gear ratio? and what motor cartridges?

36 to 48 tooth gears blue

We have physically tested that gear ratio. It has an extreme tendancy to skip when there is a torque load. That being said, it is probably a good idea to have the 36t gears be on metal that has spacers and washers to the C-Channel itself that allow perfect meshing of teeth, otherwise it will not work well.