3.25" wheels definitely do have considerably less traction, primarily due to the rubber being a lot harder and less grippy on the rollers compared to 4" and 2.75" wheels.
But they also have a lot of advantages, such as weight, slim profile, mounting hole, and convenient gear ratios that still make them perfectly viable in tipping point, however I think to eliminate the traction disadvantage, having a middle wheel which is a custom traction wheel made from flex wheels is a good idea. I use 3.25" wheels, and with this custom traction middle, I have traction which is very comparable, if not even greater, to a robot with similar weight running 4" or 2.75" 4 omni drive.
The process I went about making these wheels was initially pretty complex and overengineering, but I’ve refined it to a pretty simple method, where I sanded down the diameter of a 3.25" traction wheel:
and then I cut the rim of a 3" flex wheel from the spokes, and then cut it down width-wise to be the same width as the 3.25" traction wheel hub.
Then I put two polycarb retaining discs on either side to stop the flex wheel tire from slipping off sideways
so if there is a particular gear ratio or other reason your team has for pursuing 3.25" wheels, using a 6 wheel setup with a custom traction like this in the middle is definitely a viable option.
But all 3 wheel sizes are perfectly viable, 3.25" is just my personal favorite.